The strongest registered a magnitude of 5.2, but most were under magnitude 4, according to seismologists.
"It's a very robust sequence," said California Institute of Technology seismologist Anthony Guarino.
He believes the shaking has been due to movement along a slip fault, where two blocks of the Earth are sliding past each other.
The quakes have occurred along a seismically active part of the remote Owens Valley, about 180 miles north of Los Angeles.
An 1872 quake that was roughly 7.6 in magnitude around the same epicenter leveled the nearby town of Lone Pine.
Shaking from that temblor was felt as far away as San Diego.